Assessment of Regional Alterations of Lung Function and Structure by Hyperpolarized 3He MRI in a Murine Model of Emphysema
نویسندگان
چکیده
K. Emami, J. MacDuffie-Woodburn, C. J. Kotzer, G. A. Logan, S. Kadlecek, J. Zhu, S. Pickup, J. Yu, M. Stetz, M. Ishii, M. Stephen, P. L. Podolin, and R. Rizi Radiology, University of Pennsylvania, Philadelphia, PA, United States, Respiratory Center of Excellence for Drug Discovery, GlaxoSmithKline, King of Prussia, PA, United States, Division of Thoracic Surgery, University of Pennsylvania, Philadelphia, PA, United States, Department of Otolaryngology – Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, United States, Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, Philadelphia, PA, United States
منابع مشابه
Early changes of lung function and structure in an elastase model of emphysema--a hyperpolarized 3He MRI study.
Early changes of lung function and structure were studied in the presence of an elastase-induced model of emphysema in 35 Sprague-Dawley rats at mild (5 U/100 g) and moderate (10 U/100 g) severities. Lung ventilation was measured on a regional basis (at a planar resolution of 3.2 mm) by hyperpolarized 3He MRI at 5 and 10 wk after model induction. Subsequent to imaging, average alveolar diameter...
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